NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae
Identifieur interne : 000D66 ( Main/Exploration ); précédent : 000D65; suivant : 000D67NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae
Auteurs : Jesuthas Ajendra [Allemagne] ; Sabine Specht [Allemagne] ; Sebastian Ziewer [Allemagne] ; Andrea Schiefer [Allemagne] ; Kenneth Pfarr [Allemagne] ; Marijo Par Ina [Allemagne] ; Thomas A. Kufer [Allemagne] ; Achim Hoerauf [Allemagne] ; Marc P. Hübner [Allemagne]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) recognizes muramyl dipeptide (MDP) of bacterial cell walls, triggering NFκB-induced pro-inflammation. As most human pathogenic filariae contain
Url:
DOI: 10.1038/srep39648
PubMed: 28004792
PubMed Central: 5177913
Affiliations:
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Kufer</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Institute of Nutritional Medicine, University Hohenheim</institution>, Stuttgart,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>German Center for Infection Research (DZIF)</institution>, partner site Bonn-Cologne, Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hubner, Marc P" sort="Hubner, Marc P" uniqKey="Hubner M" first="Marc P." last="Hübner">Marc P. Hübner</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn</institution>, Bonn,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) recognizes muramyl dipeptide (MDP) of bacterial cell walls, triggering NFκB-induced pro-inflammation. As most human pathogenic filariae contain <italic>Wolbachia</italic> endobacteria that synthesize the MDP-containing cell wall precursor lipid II, NOD2’s role during infection with the rodent filaria <italic>Litomosoides sigmodontis</italic> was investigated. In NFκB reporter-cells, worm-extract containing <italic>Wolbachia</italic> induced NOD2 and NOD1. NOD2-deficient mice infected with <italic>L. sigmodontis</italic> had significantly more worms than wildtype controls early in infection. Increased worm burden was not observed after subcutaneous infection, suggesting that protective NOD2-dependent immune responses occur within the skin. Flow cytometry demonstrated that neutrophil recruitment to the skin was impaired in NOD2<sup>−/−</sup> mice after intradermal injection of third stage larvae (L3), and blood neutrophil numbers were reduced after <italic>L. sigmodontis</italic> infection. PCR array supported the requirement of NOD2 for recruitment of neutrophils to the skin, as genes associated with neutrophil recruitment and activation were downregulated in NOD2<sup>−/−</sup> mice after intradermal L3 injection. Neutrophil depletion before <italic>L. sigmodontis</italic> infection increased worm recovery in wildtype mice, confirming that neutrophils are essential against invading L3 larvae. This study indicates that NOD-like receptors are implemented in first-line protective immune responses against filarial nematodes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shaw, M H" uniqKey="Shaw M">M. H. Shaw</name></author><author><name sortKey="Reimer, T" uniqKey="Reimer T">T. Reimer</name></author><author><name sortKey="Kim, Y G" uniqKey="Kim Y">Y. G. Kim</name></author><author><name sortKey="Nunez, G" uniqKey="Nunez G">G. 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Foster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Heijenoort, J" uniqKey="Van Heijenoort J">J. van Heijenoort</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Girardin, S E" uniqKey="Girardin S">S. E. Girardin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, M" uniqKey="Wu M">M. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, S" uniqKey="Babu S">S. Babu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziewer, S" uniqKey="Ziewer S">S. Ziewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arumugam, S" uniqKey="Arumugam S">S. Arumugam</name></author><author><name sortKey="Pfarr, K M" uniqKey="Pfarr K">K. M. Pfarr</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A. Hoerauf</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Ajendra, Jesuthas" sort="Ajendra, Jesuthas" uniqKey="Ajendra J" first="Jesuthas" last="Ajendra">Jesuthas Ajendra</name></noRegion><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><name sortKey="Hubner, Marc P" sort="Hubner, Marc P" uniqKey="Hubner M" first="Marc P." last="Hübner">Marc P. Hübner</name><name sortKey="Kufer, Thomas A" sort="Kufer, Thomas A" uniqKey="Kufer T" first="Thomas A." last="Kufer">Thomas A. Kufer</name><name sortKey="Par Ina, Marijo" sort="Par Ina, Marijo" uniqKey="Par Ina M" first="Marijo" last="Par Ina">Marijo Par Ina</name><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name><name sortKey="Schiefer, Andrea" sort="Schiefer, Andrea" uniqKey="Schiefer A" first="Andrea" last="Schiefer">Andrea Schiefer</name><name sortKey="Specht, Sabine" sort="Specht, Sabine" uniqKey="Specht S" first="Sabine" last="Specht">Sabine Specht</name><name sortKey="Ziewer, Sebastian" sort="Ziewer, Sebastian" uniqKey="Ziewer S" first="Sebastian" last="Ziewer">Sebastian Ziewer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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